Enrichment of Short-Chain Ceramides and Free Fatty Acids in the Skin Epidermis, Liver, and Kidneys of db/db Mice, a Type 2 Diabetes Mellitus Model
Biomolecules & Therapeutics
;
: 457-465, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-763036
ABSTRACT
Patients with diabetes mellitus (DM) often suffer from diverse skin disorders, which might be attributable to skin barrier dysfunction. To explore the role of lipid alterations in the epidermis in DM skin disorders, we quantitated 49 lipids (34 ceramides, 14 free fatty acids (FFAs), and cholesterol) in the skin epidermis, liver, and kidneys of db/db mice, a Type 2 DM model, using UPLC-MS/MS. The expression of genes involved in lipid synthesis was also evaluated. With the full establishment of hyperglycemia at the age of 20 weeks, remarkable lipid enrichment was noted in the skin of the db/db mice, especially at the epidermis and subcutaneous fat bed. Prominent increases in the ceramides and FFAs (>3 fold) with short or medium chains (
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pele
/
Estearoil-CoA Dessaturase
/
Ceramidas
/
Receptores Citoplasmáticos e Nucleares
/
Diabetes Mellitus
/
Diabetes Mellitus Tipo 2
/
Epiderme
/
Gordura Subcutânea
/
Ácidos Graxos não Esterificados
/
Hiperglicemia
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Biomolecules & Therapeutics
Ano de publicação:
2019
Tipo de documento:
Artigo
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