Cognitive Therapy Combined with Drug Treatment in Patients with Alzheimer's Disease: A Neuropsychological and Positron Emission Tomography Investigation, a Pilot Study
Dementia and Neurocognitive Disorders
;
: 76-82, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-76325
ABSTRACT
BACKGROUND:
Cognitive therapy may have therapeutic benefit in patients with early Alzheimer's disease (AD). CASE REPORT This was a 12-week, single-blind pilot study of 4 patients with AD. The cognitive therapy included exercises for orientation to time and place; memory training, including face-name association, object recall training, and spaced retrieval; visuo-motor organization using software; similarity and ruled based categorization; and behavior modification and sequencing (e.g., making change, paying bills). The regional cerebral metabolic abnormalities and the effects of treatment on cortical metabolic responses were evaluated using 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography (PET). After 12 weeks, the participants showed slight improvement in some neuropsychological measures, and three of them showed increased regional cortical metabolism on brain PET studies.CONCLUSIONS:
Cognitive therapy may stabilize or improve cognitive and functional performance of patients with early AD and increase regional cortical metabolism of the patients' brain.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Terapia Comportamental
/
Encéfalo
/
Exercício Físico
/
Terapia Cognitivo-Comportamental
/
Projetos Piloto
/
Tomografia por Emissão de Pósitrons
/
Doença de Alzheimer
/
Aprendizagem
/
Metabolismo
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Humanos
Idioma:
Inglês
Revista:
Dementia and Neurocognitive Disorders
Ano de publicação:
2015
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS