Circulating Permeability Factors in Idiopathic Nephrotic Syndrome
Childhood Kidney Diseases
;
: 7-21, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-763268
ABSTRACT
Nephrotic syndrome (NS) is a common chronic glomerular disease in children characterized by significant proteinuria with resulting hypoalbuminemia, edema, and hyperlipidemia. Renal biopsy findings of diffuse foot processes effacement on electron microscopy and minimal change disease, focal segmental glomerulosclerosis (FSGS), or diffuse mesangial proliferation on light microscopy. It has been speculated that circulating permeability factors would be implicated in the pathogenesis of NS because they have been reportedly detected in the sera of patients and in experimental models of induced proteinuria. Moreover, a substantial portion of the patients with primary FSGS recurrence shortly after transplantation. This report reviews the current knowledge regarding the role of circulating permeability factors in the pathogenesis of proteinuria in NS and suggests future targeted therapeutic approaches for NS.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Permeabilidade
/
Proteinúria
/
Recidiva
/
Biópsia
/
Glomerulosclerose Segmentar e Focal
/
Microscopia Eletrônica
/
Hipoalbuminemia
/
Edema
/
Pé
/
Hiperlipidemias
Tipo de estudo:
Estudo prognóstico
Limite:
Criança
/
Humanos
Idioma:
Inglês
Revista:
Childhood Kidney Diseases
Ano de publicação:
2019
Tipo de documento:
Artigo
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