Correlations between embryo morphokinetic development and maternal age: Results from an intracytoplasmic sperm injection program / 대한생식의학회지
Clinical and Experimental Reproductive Medicine
; : 119-124, 2019.
Article
em En
| WPRIM
| ID: wpr-763362
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: It is widely accepted that aging decreases women’s fertility capacity. The aim of this study was to assess correlations between maternal age and the morphokinetic parameters and cleavage pattern of embryos. METHODS: The morphokinetics of embryos derived from women 40 years of age were compared retrospectively in terms of time of second polar body extrusion, time of pronuclei appearance, time of pronuclei fading, and time of two to eight discrete cells (t2–t8). Furthermore, abnormal cleavage patterns such as uneven blastomeres at the two-cell stage, cell fusion (Fu), and trichotomous mitoses (TM) were assessed. RESULTS: Only t5 occurred later in women aged 36–40 and >40 years when compared with those aged 0.05). However, Fu and TM were more common in women aged >40 years than in younger women (p<0.001). CONCLUSION: Maternal age was correlated with the cleavage pattern of embryos. Therefore, evaluating embryo morphokinetics may contribute to optimal embryo selection, thereby increasing fertility in patients with advanced maternal age.
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Índice:
WPRIM
Assunto principal:
Blastômeros
/
Envelhecimento
/
Fusão Celular
/
Estudos Retrospectivos
/
Idade Materna
/
Injeções de Esperma Intracitoplásmicas
/
Estruturas Embrionárias
/
Fertilidade
/
Corpos Polares
/
Mitose
Tipo de estudo:
Observational_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
Clinical and Experimental Reproductive Medicine
Ano de publicação:
2019
Tipo de documento:
Article