Contributing Factors to Diabetic Brain Injury and Cognitive Decline
Diabetes & Metabolism Journal
;
: 560-567, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-763690
ABSTRACT
The link of diabetes with co-occurring disorders in the brain involves complex and multifactorial pathways. Genetically engineered rodents that express familial Alzheimer's disease-associated mutant forms of amyloid precursor protein and presenilin 1 (PSEN1) genes provided invaluable insights into the mechanisms and consequences of amyloid deposition in the brain. Adding diabetes factors (obesity, insulin impairment) to these animal models to predict success in translation to clinic have proven useful at some extent only. Here, we focus on contributing factors to diabetic brain injury with the aim of identifying appropriate animal models that can be used to mechanistically dissect the pathophysiology of diabetes-associated cognitive dysfunction and how diabetes medications may influence the development and progression of cognitive decline in humans with diabetes.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Roedores
/
Encéfalo
/
Lesões Encefálicas
/
Placa Amiloide
/
Modelos Animais
/
Demência
/
Diabetes Mellitus
/
Presenilina-1
/
Amiloide
/
Insulina
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Diabetes & Metabolism Journal
Ano de publicação:
2019
Tipo de documento:
Artigo
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