Axon Guidance Molecules Guiding Neuroinflammation
Experimental Neurobiology
;
: 311-319, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-763773
ABSTRACT
Axon guidance molecules (AGMs), such as Netrins, Semaphorins, and Ephrins, have long been known to regulate axonal growth in the developing nervous system. Interestingly, the chemotactic properties of AGMs are also important in the postnatal period, such as in the regulation of immune and inflammatory responses. In particular, AGMs play pivotal roles in inflammation of the nervous system, by either stimulating or inhibiting inflammatory responses, depending on specific ligand-receptor combinations. Understanding such regulatory functions of AGMs in neuroinflammation may allow finding new molecular targets to treat neurodegenerative diseases, in which neuroinflammation underlies aetiology and progression.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Axônios
/
Neuroglia
/
Doenças Neurodegenerativas
/
Efrinas
/
Semaforinas
/
Inflamação
/
Sistema Nervoso
Tipo de estudo:
Guia de Prática Clínica
Idioma:
Inglês
Revista:
Experimental Neurobiology
Ano de publicação:
2019
Tipo de documento:
Artigo
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