Targeting Microglial and Neuronal Toll-like Receptor 2 in Synucleinopathies
Experimental Neurobiology
;
: 547-553, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-763791
ABSTRACT
Synucleinopathies are neurodegenerative disorders characterized by the progressive accumulation of α-synuclein (α-syn) in neurons and glia and include Parkinson's disease (PD) and dementia with Lewy bodies (DLB). In this review, we consolidate our key findings and recent studies concerning the role of Toll-like receptor 2 (TLR2), a pattern recognition innate immune receptor, in the pathogenesis of synucleinopathies. First, we address the pathological interaction of α-syn with microglial TLR2 and its neurotoxic inflammatory effects. Then, we show that neuronal TLR2 activation not only induces abnormal α-syn accumulation by impairing autophagy, but also modulates α-syn transmission. Finally, we demonstrate that administration of a TLR2 functional inhibitor improves the neuropathology and behavioral deficits of a synucleinopathy mouse model. Altogether, we present TLR2 modulation as a promising immunotherapy for synucleinopathies.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doença de Parkinson
/
Autofagia
/
Neuroglia
/
Corpos de Lewy
/
Doenças Neurodegenerativas
/
Demência
/
Receptores Toll-Like
/
Receptor 2 Toll-Like
/
Neuropatologia
/
Imunoterapia
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Experimental Neurobiology
Ano de publicação:
2019
Tipo de documento:
Artigo
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