Statistical Analysis of Metagenomics Data
Genomics & Informatics
;
: e6-2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-763797
ABSTRACT
Understanding the role of the microbiome in human health and how it can be modulated is becoming increasingly relevant for preventive medicine and for the medical management of chronic diseases. The development of high-throughput sequencing technologies has boosted microbiome research through the study of microbial genomes and allowing a more precise quantification of microbiome abundances and function. Microbiome data analysis is challenging because it involves high-dimensional structured multivariate sparse data and because of its compositional nature. In this review we outline some of the procedures that are most commonly used for microbiome analysis and that are implemented in R packages. We place particular emphasis on the compositional structure of microbiome data. We describe the principles of compositional data analysis and distinguish between standard methods and those that fit into compositional data analysis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Biomarcadores
/
Medicina Preventiva
/
Doença Crônica
/
Estatística como Assunto
/
Modelos Estatísticos
/
Análise de Sequência de DNA
/
Metagenoma
/
Metagenômica
/
Genoma Microbiano
/
Microbiota
Tipo de estudo:
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Genomics & Informatics
Ano de publicação:
2019
Tipo de documento:
Artigo
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