Porphyromonas gingivalis lipopolysaccharide stimulates vascular smooth muscle cell migration through signal transducer and activator of transcription 3-mediated matrix metalloproteinase-9 expression
International Journal of Oral Biology
;
: 20-26, 2019.
Artigo
em Coreano
| WPRIM
| ID: wpr-764032
ABSTRACT
Periodontal diseases have been associated with the development of cardiovascular diseases. Accumulating evidences have indicated that Porphyromonas gingivalis, a major periodontopathic pathogen, plays a critical role in the pathogenesis of atherosclerosis. In the present study, we demonstrated that P. gingivalis lipopolysaccharide (LPS) increases the mRNA and protein expression of matrix metalloproteinase-9 (MMP-9) in rat vascular smooth muscle cells. We showed that the MMP-9 expression induced by P. gingivalis LPS is mediated by the activation of signal transducer and activator of transcription 3 (STAT3) in vascular smooth muscle cells. Furthermore, the inhibition of STAT3 activity reduced P. gingivalis LPS-induced migration of vascular smooth muscle cells. Overall, our findings indicate that P. gingivalis LPS stimulates the migration of vascular smooth muscle cells via STAT3-mediated MMP-9 expression.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doenças Periodontais
/
Transdutores
/
RNA Mensageiro
/
Doenças Cardiovasculares
/
Movimento Celular
/
Porphyromonas
/
Porphyromonas gingivalis
/
Metaloproteinase 9 da Matriz
/
Aterosclerose
/
Fator de Transcrição STAT3
Limite:
Animais
Idioma:
Coreano
Revista:
International Journal of Oral Biology
Ano de publicação:
2019
Tipo de documento:
Artigo
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