Association of visceral adiposity and insulin resistance with colorectal adenoma and colorectal cancer
Intestinal Research
;
: 404-412, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-764150
ABSTRACT
BACKGROUND/AIMS:
To examine whether visceral adiposity serves as a risk factor for colorectal cancer (CRC) and colorectal adenomas.METHODS:
Two hundred healthy subjects, 200 patients with colorectal adenoma, and 151 patients with CRC (46 with early-stage and 105 with advanced-stage cancers) were enrolled at a tertiary referral hospital. All subjects underwent colonoscopy, and had laboratory data, and computed tomography (CT) scan available for abdominal fat measurement. An abdominal CT scan taken 1 to 4 years (mean interval, 20.6 months) before the diagnosis of CRC was also available in the 42 CRC patients.RESULTS:
The mean areas of visceral adipose tissue (VAT) areas in the control, adenoma, early- and advanced-stage CRC groups were 94.6, 116.8, 110.4, and 99.7 cm², respectively (P0.05). The risk of both adenoma and CRC positively correlated with fasting plasma glucose levels (P for trend <0.05). In patients with early-stage cancer (n=17), VAT area decreased when the CT scan at diagnosis was compared with that taken before the diagnosis of CRC, but superficial adipose tissue area did not, so visceral-to-total fat ratio significantly decreased (46.6% vs. 50.7%, respectively, P=0.018)CONCLUSIONS:
VAT area is related to the risk of colorectal adenoma. However, VAT decreases from the early stages of CRC. Impaired fasting glucose has a role in colorectal carcinogenesis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Glicemia
/
Resistência à Insulina
/
Neoplasias Colorretais
/
Tomografia Computadorizada por Raios X
/
Adenoma
/
Tecido Adiposo
/
Fatores de Risco
/
Colonoscopia
/
Jejum
/
Diagnóstico
Tipo de estudo:
Estudo diagnóstico
/
Estudo de etiologia
/
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Intestinal Research
Ano de publicação:
2019
Tipo de documento:
Artigo
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