Stem cell-based therapy for inflammatory bowel disease
Intestinal Research
;
: 311-316, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-764160
ABSTRACT
Inflammatory bowel disease (IBD) is an idiopathic, multi-etiological disease characterized by inflammation and mucosal destruction of the gastrointestinal tract. Despite the remarkable advance in immunomodulating therapies, there still remains a certain population of patients who are refractory to conventional as well as biologic therapies and fail to achieve mucosal healing. To improve the prognosis of those patients, at least 2 types of stem cells have been tested for their potential therapeutic use. Transplantation of hematopoietic stem cells or mesenchymal stem cells have been tested in several clinical studies, but their beneficial effect still remains controversial. In this review, we would like to overview the recent clinical challenges of stem cell-based therapies in IBD and also introduce our new therapeutic plan of intestinal stem cell transplantation for IBD, based on our ex vivo intestinal organoid culture technique.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Células-Tronco
/
Terapia Biológica
/
Células-Tronco Hematopoéticas
/
Doenças Inflamatórias Intestinais
/
Organoides
/
Transplante de Células-Tronco
/
Trato Gastrointestinal
/
Técnicas de Cultura
/
Células-Tronco Mesenquimais
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Intestinal Research
Ano de publicação:
2019
Tipo de documento:
Artigo
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