Effects of Dexmedetomidine Infusion During Sevoflurane Anesthesia on Otoacoustic Emissions
Journal of Audiology & Otology
; : 89-95, 2019.
Article
em En
| WPRIM
| ID: wpr-764209
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES: Knowing the ototoxic potential of the agents used in medical treatments is important for the protection of hearing. Although we have knowledge regarding some effects of dexmedetomidine, which is an anesthetic-sparing drug, its influence over the hearing system has never been studied and is obscure yet. The aim of this study is to determine the effects of intravenous dexmedetomidine application during sevoflurane anesthesia on otoacoustic emissions (OAEs). SUBJECTS AND METHODS: This prospective randomized study was performed on 60 patients (34 male, 26 female, mean age: 30.6±9.2 years) who were scheduled for an elective surgery under general anesthesia and the patients were enrolled and randomly divided into 2 groups. They received dexmedetomidine (Group D) or Saline (Group S) infusion during a standardized Sevoflurane anesthesia. Transient and distortion product OAEs were measured preoperatively and postoperatively (24th hour). OAE results were compared within and between groups. RESULTS: In group D postoperative OAEs were lower than preoperative OAEs and postoperative levels of group S, especially at low frequencies (p<0.05). CONCLUSIONS: Dexmedetomidine infusion affects the micromechanical function of cochlea especially in the low-frequency region. Dexmedetomidine should be carefully used during general anesthesia to avoid its probable harmful effects on cochlear micromechanics.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Estudos Prospectivos
/
Cóclea
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Dexmedetomidina
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Agonistas de Receptores Adrenérgicos alfa 2
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Audição
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Anestesia
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Anestesia Geral
Tipo de estudo:
Clinical_trials
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Observational_studies
Limite:
Female
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Humans
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Male
Idioma:
En
Revista:
Journal of Audiology & Otology
Ano de publicação:
2019
Tipo de documento:
Article