The Role of Peroxiredoxin Family in Cancer Signaling
Journal of Cancer Prevention
;
: 65-71, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-764308
ABSTRACT
Peroxiredoxins (Prxs) are antioxidant enzymes that protect cells from oxidative stress by reducing intracellular accumulation of reactive oxygen species (ROS). In mammalian cells, the six Prx isoforms are ubiquitously expressed in diverse intracellular locations. They are involved in the regulation of various physiological processes including cell growth, differentiation, apoptosis, immune response and metabolism as well as intracellular ROS homeostasis. Although there are increasing evidences that Prxs are involved in carcinogenesis of many cancers, their role in cancer is controversial. The ROS levels in cancer cells are increased compared to normal cells, thus promoting cancer development. Nevertheless, for various cancer types, an overexpression of Prxs has been found to be associated with poor patient prognosis, and an increasing number of studies have reported that tumorigenesis is either facilitated or inhibited by regulation of cancer-associated signaling pathways. This review summarizes Prx isoforms and their basic functions, the relationship between the expression level and the physiological role of Prxs in cancer cells, and their roles in regulating cancer-associated signaling pathways.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Espécies Reativas de Oxigênio
/
Apoptose
/
Estresse Oxidativo
/
Isoformas de Proteínas
/
Peroxirredoxinas
/
Fenômenos Fisiológicos
/
Carcinogênese
/
Homeostase
/
Metabolismo
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Journal of Cancer Prevention
Ano de publicação:
2019
Tipo de documento:
Artigo
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