Mosapride Accelerates the Delayed Gastric Emptying of High-Viscosity Liquids: A Crossover Study Using Continuous Real-Time 13C Breath Test (BreathID System)
Journal of Neurogastroenterology and Motility
;
: 395-401, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-76464
ABSTRACT
BACKGROUND/AIMS:
The administration of liquid nutrients to patients is often accompanied by complications such as gastroesophageal reflux. To prevent gastroesophageal reflux, high-viscosity liquid meals are used widely, however, it still remains controversial whether high-viscosity liquid meals have any effect on the rate of gastric emptying. The present study was conducted with the aim of determining whether high-viscosity liquid meals had any effect on the rate of gastric emptying and mosapride might accelerate the rate of gastric emptying of high-viscosity liquid meals.METHODS:
Six healthy male volunteers underwent 3 tests at intervals of > 1 week. After fasting for > 8 hours, each subject received one of three test meals (liquid meal only, high-viscosity liquid meal [liquid meal plus pectin] only, or high-viscosity liquid meal 30 minutes after intake of mosapride). A 13C-acetic acid breath test was performed, which monitored the rate of gastric emptying for 4 hours. Using the Oridion Research Software (beta version), breath test parameters were calculated. The study parameters were examined for all the 3 test conditions and compared using the Freidman test.RESULTS:
Gastric emptying was significantly delayed following intake of a high-viscosity liquid meal alone as compared with a liquid meal alone; however, intake of mosapride prior to a high-viscosity liquid meal was associated with a significantly accelerated rate of gastric emptying as compared with a high-viscosity liquid meal alone.CONCLUSIONS:
This study showed that high-viscosity liquid meals delayed gastric emptying however, mosapride recovered the delayed rate of gastric emptying by high-viscosity liquid meals.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Benzamidas
/
Testes Respiratórios
/
Refluxo Gastroesofágico
/
Morfolinas
/
Jejum
/
Pectinas
/
Estudos Cross-Over
/
Refeições
/
Esvaziamento Gástrico
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Journal of Neurogastroenterology and Motility
Ano de publicação:
2011
Tipo de documento:
Artigo
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