Influence of Short- and Long-term High-dose Caffeine Administration on Behavior in an Animal Model of Adolescence
Journal of Korean Biological Nursing Science
;
: 217-223, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-764750
ABSTRACT
PURPOSE:
Caffeine is the most widely consumed psychostimulant of the methylxanthine class. Among adolescents, high-dose of caffeine consumption has increased rapidly over the last few decades due to the introduction of energy drinks. However, little is known about the time-dependent effect of high doses of caffeine consumption in adolescents. The present study aims to examine the short- and long-term influence of high-dose caffeine on behavior of adolescence.METHODS:
The animals were divided into three groups a “vehicle” group, which was injected with 1 ml of phosphate-buffered saline for 14 days; a “Day 1” group, which was injected with caffeine (30 mg/kg), 2 h before the behavioral tests; and a “Day 14” group, which was infused with caffeine for 14 days. An open-field test, a Y-maze test, and a passive avoidance test were conducted to assess the rats'activity levels, anxiety, and cognitive function.RESULTS:
High-dose caffeine had similar effects in short-and long-term treatment groups. It increased the level of locomotor activity and anxiety-like behavior, as evidenced by the increase in the number of movements and incidences of rearing and grooming in the caffeine-treated groups. No significant differences were observed between the groups in the Y-maze test. However, in the passive avoidance test, the escape latency in the caffeine-treated group was decreased significantly, indicating impaired memory acquisition.CONCLUSION:
These results indicate that high-dose caffeine in adolescents may increase locomotor activity and anxiety-like behavior and impair learning and memory, irrespective of the duration of administration. The findings will be valuable for both evidence-based education and clinical practice.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ansiedade
/
Nações Unidas
/
Cafeína
/
Incidência
/
Cognição
/
Modelos Animais
/
Educação
/
Bebidas Energéticas
/
Escala de Avaliação Comportamental
/
Asseio Animal
Tipo de estudo:
Estudo de incidência
/
Estudo prognóstico
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Journal of Korean Biological Nursing Science
Ano de publicação:
2019
Tipo de documento:
Artigo
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