Your browser doesn't support javascript.
loading
The Long-Acting Injectable Antipsychotics in Clinical Practice / 신경정신의학
Journal of Korean Neuropsychiatric Association ; : 29-37, 2019.
Artigo em Coreano | WPRIM | ID: wpr-765189
ABSTRACT
Symptomatic relapse is observed frequently and often associated with social and/or occupational decline that can be difficult to reverse in patients with schizophrenia. Several atypical antipsychotics, including risperidone, olanzapine, paliperidone, and aripiprazole, have become available as long-acting injectable antipsychotics (LAIs), and new evidence has been accumulating. LAIs appear to have a significant role in at least a group of schizophrenia patients. Improving the adherence, continuous availability, managing changes in receptor sensitivity, and lowering the requirement of cumulative doses are some of the major advantages of LAIs. Patients with first episode psychosis, dopamine super-sensitivity syndromes, and comorbid substance abuse might particularly benefit. Delaying the initiation of LAI until the establishment of non-adherence is not recommended. The results of clinical trials comparing LAIs with oral antipsychotics (OAPs) are inconsistent because they are influenced considerably by the study design. On the other hand, several barriers to LAIs use in current practice include clinical lack of knowledge, and negative attitudes about LAIs. This article tries to help clinicians better characterize the role of LAIs in the treatment of schizophrenia.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Transtornos Psicóticos / Recidiva / Esquizofrenia / Antipsicóticos / Dopamina / Risperidona / Transtornos Relacionados ao Uso de Substâncias / Adesão à Medicação / Palmitato de Paliperidona / Aripiprazol Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Coreano Revista: Journal of Korean Neuropsychiatric Association Ano de publicação: 2019 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Transtornos Psicóticos / Recidiva / Esquizofrenia / Antipsicóticos / Dopamina / Risperidona / Transtornos Relacionados ao Uso de Substâncias / Adesão à Medicação / Palmitato de Paliperidona / Aripiprazol Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Coreano Revista: Journal of Korean Neuropsychiatric Association Ano de publicação: 2019 Tipo de documento: Artigo