Your browser doesn't support javascript.
loading
Microelectric Treatment by Transcutaneous Electrical Nerve Stimulation in a Rat Model of Acute Spinal Cord Injury
Journal of Korean Society of Spine Surgery ; : 1-10, 2019.
Artigo em Inglês | WPRIM | ID: wpr-765625
ABSTRACT
STUDY

DESIGN:

Animal study.

OBJECTIVES:

To investigate the effects of microelectric treatment by transcutaneous electrical nerve stimulation (TENS) on functional recovery and histological changes in a rat model of spinal cord injury (SCI). SUMMARY OF LITERATURE REVIEW The effects of TENS on spasticity and its underlying mechanisms remain unclear. MATERIALS AND

METHODS:

SCI was induced by a 1.5-mm impactor with 200,000–260,000 dyne after laminectomy. Rats were divided into the following groups group I (normal control), group II (microelectric treatment of 0 A), group III (microelectric treatment of 100 µA for 1 hr/day), group IV (microelectric treatment of 400 µA for 1 hr/day), and group V (microelectric treatment of 400 µA for 24 hr/day). After inducing SCI, rats were assessed by a sensory test with von Frey filaments and the locomotor recovery test (BBB rating scale) at 1, 4, 7, 14, 21, and 28 days. To evaluate spinal cord damage, histopathological studies were performed with hematoxylin and eosin. Brain-derived neurotrophic factor (BDNF) and TrkB immunohistochemistry studies were performed at 28 days.

RESULTS:

In groups IV and V, the BBB score had significantly improved on days 21 and 28 after SCI, and the TENS-treated groups showed significant neuronal recovery. After SCI, groups IV and V showed a significant recovery of locomotor function and the motor sensory response of the withdrawal threshold to 3.5 g. In addition, necrotic tissue and cystic spaces in the spinal cord were significantly reduced and BDNF/TrkB-positive cells were highly expressed in groups III, IV, and V.

CONCLUSIONS:

Microelectric treatment can play a role in facilitating the recovery of locomotion following SCI.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Medula Espinal / Traumatismos da Medula Espinal / Imuno-Histoquímica / Estimulação Elétrica Nervosa Transcutânea / Amarelo de Eosina-(YS) / Fator Neurotrófico Derivado do Encéfalo / Modelos Animais / Hematoxilina / Laminectomia / Locomoção Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Inglês Revista: Journal of Korean Society of Spine Surgery Ano de publicação: 2019 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Medula Espinal / Traumatismos da Medula Espinal / Imuno-Histoquímica / Estimulação Elétrica Nervosa Transcutânea / Amarelo de Eosina-(YS) / Fator Neurotrófico Derivado do Encéfalo / Modelos Animais / Hematoxilina / Laminectomia / Locomoção Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Inglês Revista: Journal of Korean Society of Spine Surgery Ano de publicação: 2019 Tipo de documento: Artigo