Established and Emerging Mechanisms of Diabetic Cardiomyopathy
Journal of Lipid and Atherosclerosis
;
: 26-47, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-765654
ABSTRACT
Diabetes mellitus increases the risk for the development of heart failure even in the absence of coronary artery disease and hypertension, a cardiac entity termed diabetic cardiomyopathy (DC). Clinically, DC is increasingly recognized and typically characterized by concentric cardiac hypertrophy and diastolic dysfunction, ultimately resulting in heart failure with preserved ejection fraction (HFpEF) and potentially even heart failure with reduced ejection fraction (HFrEF). Numerous molecular mechanisms have been proposed to underlie the alterations in myocardial structure and function in DC, many of which show similar alterations in the failing heart. Well investigated and established mechanisms of DC include increased myocardial fibrosis, enhanced apoptosis, oxidative stress, impaired intracellular calcium handling, substrate metabolic alterations, and inflammation, among others. In addition, a number of novel mechanisms that receive increasing attention have been identified in recent years, including autophagy, dysregulation of microRNAs, epigenetic mechanisms, and alterations in mitochondrial protein acetylation, dynamics and quality control. This review aims to provide an overview and update of established underlying mechanisms of DC, as well as a discussion of recently identified and emerging mechanisms that may also contribute to the structural and functional alterations in DC.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Acetilação
/
Controle de Qualidade
/
Autofagia
/
Doença da Artéria Coronariana
/
Fibrose
/
Cálcio
/
Apoptose
/
Cardiomegalia
/
Estresse Oxidativo
/
Proteínas Mitocondriais
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Journal of Lipid and Atherosclerosis
Ano de publicação:
2019
Tipo de documento:
Artigo
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