Vitamin D Status and Vitamin D Receptor Gene Polymorphisms Are Associated with Pelvic Floor Disorders in Women
Journal of Menopausal Medicine
;
: 119-126, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-765736
ABSTRACT
OBJECTIVES:
To investigate if vitamin D receptor (VDR) gene polymorphisms and circulating vitamin D levels are associated with pelvic floor disorders (PFDs).METHODS:
In this case-control study, 25-hydroxy-vitamin D (25[OH]D) serum levels were analyzed in 47 females with PFDs and 87 healthy females (controls), respectively. The VDR gene polymorphisms were determined by using polymerase chain reaction and performing digestions with 4 restriction enzymes i.e., ApaI, TaqI, FokI, and BsmI. Vitamin D levels of patients were divided into 0.05). However, there was a significant difference in the distribution of vitamin D levels between study group and controls using Pearson's χ2 test (30 ng/mL 87.2%, 12.8%, and 0% in the study group and 75.9%, 16.1%, and 8.0% in controls, respectively, P < 0.05). Taken together, our observations suggest that vitamin D levels could be associated with PFDs and that 2 polymorphisms (i.e., ApaI and BsmI) in the VDR gene may contribute to an increased prevalence of PFDs in women with insufficient levels of vitamin D.CONCLUSIONS:
Examining vitamin D levels and performing a VDR genotype analysis may be helpful for assessing PFD risk.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Vitamina D
/
Deficiência de Vitamina D
/
Vitaminas
/
Estudos de Casos e Controles
/
Reação em Cadeia da Polimerase
/
Prevalência
/
Receptores de Calcitriol
/
Diafragma da Pelve
/
Distúrbios do Assoalho Pélvico
/
Genótipo
Tipo de estudo:
Estudo observacional
/
Estudo de prevalência
/
Fatores de risco
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Journal of Menopausal Medicine
Ano de publicação:
2018
Tipo de documento:
Artigo
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