The Beneficial and Adverse Effects of Raloxifene in Menopausal Women: A Mini Review
Journal of Menopausal Medicine
; : 183-187, 2018.
Article
em En
| WPRIM
| ID: wpr-765748
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVES: The present mini review aimed to summarize the existing knowledge regarding the beneficial and adverse effects of raloxifene in menopausal women. METHODS: This study is a review of relevant publications about the effects of raloxifene on sleep disorder, depression, venous thromboembolism, the plasma concentration of lipoprotein, breast cancer, and cognitive function among menopausal women. RESULTS: Raloxifene showed no significant effect on depression and sleep disorder. Verbal memory improved with administration of 60 mg/day of raloxifene while a mild cognitive impairment risk reduction by 33% was observed with administration of 120 mg/day of raloxifene. Raloxifene was associated with a 50% decrease in the need for prolapse surgery. The result of a meta-analysis showed a significant decline in the plasma concentration of lipoprotein in the raloxifene group compared to placebo (standardized mean difference, −0.43; 10 trials). A network meta-analysis showed that raloxifene significantly decreased the risk of breast cancer (relative risk, 0.572; 95% confidence interval, 0.327–0.881; P = 0.01). In terms of adverse effects of raloxifene, the odds ratio (OR) was observed to be 1.54 (P = 0.006), indicating 54% increase in the risk of deep vein thrombosis (DVT) while the OR for pulmonary embolism (PE) was 1.05, suggesting a 91% increase in the risk of PE alone (P = 0.03). CONCLUSIONS: Raloxifene had no significant effect on depression and sleep disorder but decreased the concentration of lipoprotein. Raloxifene administration was associated with an increased risk of DVT and PE and a decreased risk of breast cancer and pelvic organ prolapse in postmenopausal women.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Plasma
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Prolapso
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Embolia Pulmonar
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Transtornos do Sono-Vigília
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Neoplasias da Mama
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Razão de Chances
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Cognição
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Trombose Venosa
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Cloridrato de Raloxifeno
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Comportamento de Redução do Risco
Tipo de estudo:
Clinical_trials
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Etiology_studies
/
Systematic_reviews
Limite:
Female
/
Humans
Idioma:
En
Revista:
Journal of Menopausal Medicine
Ano de publicação:
2018
Tipo de documento:
Article