Modeling α-Synuclein Propagation with Preformed Fibril Injections
Journal of Movement Disorders
;
: 139-151, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-765866
ABSTRACT
The aggregation of α-synuclein (α-syn) has been implicated in the pathogenesis of many neurodegenerative disorders, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Postmortem analyses of α-syn pathology, especially that of PD, have suggested that aggregates progressively spread from a few discrete locations to wider brain regions. The neuron-to-neuron propagation of α-syn has been suggested to be the underlying mechanism by which aggregates spread throughout the brain. Many cellular and animal models has been created to study cell-to-cell propagation. Recently, it has been shown that a single injection of preformed fibrils (PFFs) made of recombinant α-syn proteins into various tissues and organs of many different animal species results in widespread α-syn pathology in the central nervous system (CNS). These PFF models have been extensively used to study the mechanism by which aggregates spread throughout the brain. Here, we review what we have learned from PFF models, describe the nature of PFFs and the neuropathological features, neurophysiological characteristics, and behavioral outcomes of the models.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doença de Parkinson
/
Patologia
/
Encéfalo
/
Sistema Nervoso Central
/
Corpos de Lewy
/
Atrofia de Múltiplos Sistemas
/
Doenças Neurodegenerativas
/
Modelos Animais
/
Demência
/
Alfa-Sinucleína
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Journal of Movement Disorders
Ano de publicação:
2019
Tipo de documento:
Artigo
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