Corticosteroid Treatment in Autoimmune Encephalitis
Journal of Neurocritical Care
;
(2): 60-68, 2017.
Artigo
em Coreano
| WPRIM
| ID: wpr-765891
ABSTRACT
An increasing number of neuronal autoantibodies which target cell surface or synaptic proteins have been discovered over the last decade. Autoimmune encephalitis refers to this new category of autoimmune-mediated neurological disorders, which involve the central nervous system. Recent studies have established that autoimmune encephalitis is now the major cause of encephalitis, which was previously considered to be encephalitis of an unknown etiology. Moreover, the fact that autoimmune encephalitis is potentially treatable with immunomodulating therapy has changed the paradigm for the diagnosis and treatment of acute encephalitis syndrome. We herein review the pathophysiology, clinical manifestations, diagnosis, and treatment of autoimmune encephalitis with a focus on corticosteroid therapy as the first-line immunotherapy. In addition, regarding the diagnostic approach, we emphasize the differentiation between autoimmune and infectious encephalitis, because this distinction is not necessarily clear-cut in real clinical practice and should be considered when determining the initiation and type of immunotherapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Autoanticorpos
/
Sistema Nervoso Central
/
Doenças Autoimunes do Sistema Nervoso
/
Diagnóstico
/
Encefalite
/
Encefalite Infecciosa
/
Glucocorticoides
/
Imunoterapia
/
Doenças do Sistema Nervoso
/
Neurônios
Tipo de estudo:
Estudo diagnóstico
Idioma:
Coreano
Revista:
Journal of Neurocritical Care
Ano de publicação:
2017
Tipo de documento:
Artigo
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