Tie2 is tied at the cell-cell contacts and to extracellular matrix by Angiopoietin-1
Experimental & Molecular Medicine
;
: 133-139, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-76617
ABSTRACT
Angiopoietin-1 (Ang1) binds to and activates Tie2 receptor tyrosine kinase. Ang1-Tie2 signal has been proposed to exhibit two opposite roles in the controlling blood vessels. One is vascular stabilization and the other is vascular angiogenesis. There has been no answer to the question as to how Tie2 induces two opposite responses to the same ligand. Our group and Dr. Alitalo's group have demonstrated that trans-associated Tie2 at cell-cell contacts and extracellular matrix (ECM)-anchored Tie2 play distinct roles in the endothelial cells. The complex formation depends on the presence or absence of cell-cell adhesion. Here, we review how Ang1-Tie2 signal regulates vascular maintenance and angiogenesis. We further point to the unanswered questions that must be clarified to extend our knowledge of vascular biology and to progress basic knowledge to the treatment of the diseases in which Ang1-Tie2-mediated signal is central.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Endotélio Vascular
/
Transdução de Sinais
/
Adesão Celular
/
Movimento Celular
/
Neovascularização Fisiológica
/
Células Endoteliais
/
Receptor TIE-2
/
Angiopoietina-1
/
Matriz Extracelular
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2009
Tipo de documento:
Artigo
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