Asymptomatic Cerebral Small Vessel Disease: Insights from Population-Based Studies / 대한뇌졸중학회지
Journal of Stroke
;
: 121-138, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-766253
ABSTRACT
Cerebral small vessel disease (CSVD) is a common group of neurological conditions that confer a significant burden of morbidity and mortality worldwide. In most cases, CSVD is only recognized in its advanced stages once its symptomatic sequelae develop. However, its significance in asymptomatic healthy populations remains poorly defined. In population-based studies of presumed healthy elderly individuals, CSVD neuroimaging markers including white matter hyperintensities, lacunes, cerebral microbleeds, enlarged perivascular spaces, cortical superficial siderosis, and cerebral microinfarcts are frequently detected. While the presence of these imaging markers may reflect unique mechanisms at play, there are likely shared pathways underlying CSVD. Herein, we aim to assess the etiology and significance of these individual biomarkers by focusing in asymptomatic populations at an epidemiological level. By primarily examining population-based studies, we explore the risk factors that are involved in the formation and progression of these biomarkers. Through a critical semi-systematic review, we aim to characterize “asymptomatic” CSVD, review screening modalities, and draw associations from observational studies in clinical populations. Lastly, we highlight areas of research (including therapeutic approaches) in which further investigation is needed to better understand asymptomatic CSVD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Biomarcadores
/
Siderose
/
Programas de Rastreamento
/
Epidemiologia
/
Fatores de Risco
/
Mortalidade
/
Leucoaraiose
/
Doenças de Pequenos Vasos Cerebrais
/
Acidente Vascular Cerebral Lacunar
/
Neuroimagem
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
/
Estudo de rastreamento
Limite:
Idoso
/
Humanos
Idioma:
Inglês
Revista:
Journal of Stroke
Ano de publicação:
2019
Tipo de documento:
Artigo
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