History of Migraine and Volume of Brain Infarcts: The Italian Project on Stroke at Young Age (IPSYS) / 대한뇌졸중학회지
Journal of Stroke
;
: 324-331, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-766259
ABSTRACT
BACKGROUND AND PURPOSE:
Migraine has been shown to increase cerebral excitability, promote rapid infarct expansion into tissue with perfusion deficits, and result in larger infarcts in animal models of focal cerebral ischemia. Whether these effects occur in humans has never been properly investigated.METHODS:
In a series of consecutive patients with acute ischemic stroke, enrolled in the setting of the Italian Project on Stroke at Young Age, we assessed acute as well as chronic infarct volumes by volumetric magnetic resonance imaging, and compared these among different subgroups identified by migraine status.RESULTS:
A cohort of 591 patients (male, 53.8%; mean age, 37.5±6.4 years) qualified for the analysis. Migraineurs had larger acute infarcts than non-migraineurs (median, 5.9 cm³ [interquartile range (IQR), 1.4 to 15.5] vs. 2.6 cm³ [IQR, 0.8 to 10.1], P<0.001), and the largest volumes were observed in patients with migraine with aura (median, 9.0 cm³ [IQR, 3.4 to 16.6]). In a linear regression model, migraine was an independent predictor of increased log (acute infarct volumes) (median ratio [MR], 1.64; 95% confidence interval [CI], 1.22 to 2.20), an effect that was more prominent for migraine with aura (MR, 2.92; 95% CI, 1.88 to 4.54).CONCLUSIONS:
These findings reinforce the experimental observation of larger acute cerebral infarcts in migraineurs, extend animal data to human disease, and support the hypothesis of increased vulnerability to ischemic brain injury in people suffering migraine.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Perfusão
/
Depressão Alastrante da Atividade Elétrica Cortical
/
Encéfalo
/
Lesões Encefálicas
/
Imageamento por Ressonância Magnética
/
Modelos Lineares
/
Isquemia Encefálica
/
Fatores de Risco
/
Estudos de Coortes
/
Acidente Vascular Cerebral
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Journal of Stroke
Ano de publicação:
2019
Tipo de documento:
Artigo
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