Replication of the results of genome-wide and candidate gene association studies on telomere length in a Korean population
The Korean Journal of Internal Medicine
;
: 719-726, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-76671
ABSTRACT
BACKGROUND/AIMS:
A number of genome-wide and candidate gene association studies have identified polymorphisms associated with telomere length in Caucasian populations. This study was conducted to determine the impacts of 17 polymorphisms identified in Caucasians on telomere length in a Korean population.METHODS:
Ninety-four healthy individuals were enrolled in this study. Relative telomere length of chromosomes from peripheral blood samples was measured using quantitative polymerase chain reaction.RESULTS:
Two polymorphisms, rs10936599 of MYNN and rs412658 of ZNF676, were found to be associated w ith telomere length (under dominant model, p = 0.04; under recessive model, p = 0.001). Three polymorphisms, rs2853669, rs7705526, and rs2736108, at the TERT locus were also associated with telomere length (under recessive model, p = 0.01, p = 0.02, and p = 0.01, respectively). The genotypes of the five polymorphisms associated with short telomere length were considered bad genotypes; telomere length was significantly decreased with increasing number of bad genotypes (p= 1.7 x 10(-5)).CONCLUSIONS:
We have identified polymorphisms associated with telomere length in a Korean population.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenótipo
/
Estudos de Casos e Controles
/
Dedos de Zinco
/
Telômero
/
Telomerase
/
Polimorfismo de Nucleotídeo Único
/
Povo Asiático
/
Proteínas de Ligação a DNA
/
Fatores de Transcrição Kruppel-Like
/
Estudo de Associação Genômica Ampla
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
The Korean Journal of Internal Medicine
Ano de publicação:
2015
Tipo de documento:
Artigo
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