A case of Neuroblasoma with multiple skeletal metastasis / 대한정형외과학회잡지

ABSTRACT

Neuroblastoma is a malignant tumor of sympathetic nerve origin. They are derived from sympathetic formative cells, the primitive neuroblasts that have failed to mature. They may be located wherever sympathetic nerve tissue is found, The majority of cases occured in the suprarenal medulla, posterior mediastinum, and orbit. The tumor metastasized early by the hematogenous or lympathic route, or both to skeletal system, liver, and skin, etc. Since the vast majority of children with neuroblastoma have local or distant metastases at the time of original diagnosis, the clinical manifestation and the prognosis are variable. The age distribution is from birth to 19 years old. Many methods of treatment of neuroblastoma have been advocated such as surgical excision,roentgen thrapy, and its combipation therapy but the effect is questionable. Here, it is reported a case of neuroblastoma with systemic skeletal metastasis originated from posterior mediastinum in 8 years old girl.