Genetic Polymorphisms in VIR Genes among Indian Plasmodium vivax Populations
The Korean Journal of Parasitology
;
: 557-564, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-76771
ABSTRACT
The vir genes are antigenic genes and are considered to be possible vaccine targets. Since India is highly endemic to Plasmodium vivax, we sequenced 5 different vir genes and investigated DNA sequence variations in 93 single-clonal P. vivax isolates. High variability was observed in all the 5 vir genes; the vir 1/9 gene was highly diverged across Indian populations. The patterns of genetic diversity do not follow geographical locations, as geographically distant populations were found to be genetically similar. The results in general present complex genetic diversity patterns in India, requiring further in-depth population genetic and functional studies.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Filogenia
/
Plasmodium vivax
/
Polimorfismo Genético
/
Proteínas de Protozoários
/
Malária Vivax
/
Índia
/
Antígenos de Protozoários
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
The Korean Journal of Parasitology
Ano de publicação:
2014
Tipo de documento:
Artigo
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