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Effect of extramucin pools in gastric cancer patients
Annals of Surgical Treatment and Research ; : 254-260, 2015.
Artigo em Inglês | WPRIM | ID: wpr-76945
ABSTRACT

PURPOSE:

Mucinous gastric adenocarcinoma (MGC) is defined by the World Health Organization as a gastric adenocarcinoma with >50% extracellular mucin pools within the tumors. In this study, we attempted to analyze the clinicopathologic features of patients pathologically diagnosed as gastric cancer with lower than 50% tumor volume of extracellular mucin pool adenocarcinoma (LEMPC). We compared MGC versus nonmucinous gastric adenocarcinoma (NMGC). We were used in abbreviations LEMPC for NMGC including extracellular mucin pool.

METHODS:

Files of 995 patients with gastric cancer NMGC (n = 935), MGC (n = 20), LEMPC (n = 40) who underwent curative resection at Pusan National University Yangsan Hospital from December 2008 to December 2013 were retrospectively analyzed. All pathologic reports after curative resection and evaluated clinicopathologic features were reviewed to identify the effect of extracellular mucin pools in gastric cancer.

RESULTS:

Compared with the NMGC patients, the clinicopathological features of MGC patients were as follows more frequent open surgery, larger tumor size, more advanced T stage and N stage, more positive lymph node metastasis, and perineural invasion. LEMPC patients showed similar features compared with NMGC patients. MGC and LEMPC patients showed similar clinicopathological features, except T stage and lymph node metastasis.

CONCLUSION:

LEMPC can be thought of as a previous step of MGC. It is reasonable to consider LEMPC patients in the diagnostic criteria of MGC, and to adequately treat.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Estômago / Neoplasias Gástricas / Organização Mundial da Saúde / Adenocarcinoma / Estudos Retrospectivos / Adenocarcinoma Mucinoso / Abreviaturas / Carga Tumoral / Linfonodos / Mucinas Tipo de estudo: Estudo observacional Limite: Humanos Idioma: Inglês Revista: Annals of Surgical Treatment and Research Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Estômago / Neoplasias Gástricas / Organização Mundial da Saúde / Adenocarcinoma / Estudos Retrospectivos / Adenocarcinoma Mucinoso / Abreviaturas / Carga Tumoral / Linfonodos / Mucinas Tipo de estudo: Estudo observacional Limite: Humanos Idioma: Inglês Revista: Annals of Surgical Treatment and Research Ano de publicação: 2015 Tipo de documento: Artigo