Adoptive cell transfer therapy for hepatocellular carcinoma / 医学前沿
Frontiers of Medicine
;
(4): 3-11, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-771266
ABSTRACT
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. This malignancy is associated with poor prognosis and high mortality. Novel approaches for prolonging the overall survival of patients with advanced HCC are urgently needed. The antitumor activities of adoptive cell transfer therapy (ACT), such as strategies based on tumor-infiltrating lymphocytes and cytokine-induced killer cells, are more effective than those of traditional strategies. Currently, chimeric antigen receptor T-cell (CAR-T) immunotherapy has achieved numerous breakthroughs in the treatment of hematological malignancies, including relapsed or refractory lymphoblastic leukemia and refractory large B-cell lymphoma. Nevertheless, this approach only provides a modest benefit in the treatment of solid tumors. The clinical results of CAR-T immunotherapy for HCC that could be obtained at present are limited. Some published studies have demonstrated that CAR-T could inhibit tumor growth and cause severe side effects. In this review, we summarized the current application of ACT, the challenges encountered by CAR-T technology in HCC treatment, and some possible strategies for the future direction of immunotherapeutic research.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Terapêutica
/
Linfócitos T
/
Ensaios Clínicos Controlados Aleatórios como Assunto
/
Imunoterapia Adotiva
/
Linfócitos do Interstício Tumoral
/
Carcinoma Hepatocelular
/
Transferência Adotiva
/
Biologia Celular
/
Alergia e Imunologia
/
Receptores de Antígenos Quiméricos
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Humanos
Idioma:
Inglês
Revista:
Frontiers of Medicine
Ano de publicação:
2019
Tipo de documento:
Artigo
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