Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells / 医学前沿
Frontiers of Medicine
;
(4): 374-386, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-771300
ABSTRACT
A family of transcription factors known as Id proteins, or inhibitor of DNA binding and differentiation, is capable of regulating cell proliferation, survival and differentiation, and is often upregulated in multiple types of tumors. Due to their ability to promote self-renewal, Id proteins have been considered as oncogenes, and potential therapeutic targets in cancer models. On the contrary, certain Id proteins are reported to act as tumor suppressors in the development of Burkitt's lymphoma in humans, and hepatosplenic and innate-like T cell lymphomas in mice. The contexts and mechanisms by which Id proteins can serve in such contradictory roles to determine tumor outcomes are still not well understood. In this review, we explore the roles of Id proteins in lymphocyte development and tumorigenesis, particularly with respect to inhibition of their canonical DNA binding partners known as E proteins. Transcriptional regulation by E proteins, and their antagonism by Id proteins, act as gatekeepers to ensure appropriate lymphocyte development at key checkpoints. We re-examine the derailment of these regulatory mechanisms in lymphocytes that facilitate tumor development. These mechanistic insights can allow better appreciation of the context-dependent roles of Id proteins in cancers and improve considerations for therapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Fatores de Transcrição
/
Linfócitos
/
Fenômenos Fisiológicos Celulares
/
Proteínas Supressoras de Tumor
/
Proteína 1 Inibidora de Diferenciação
/
Carcinogênese
/
Metabolismo
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Frontiers of Medicine
Ano de publicação:
2018
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS