A new isoflavone derivative from Rosa Damascena and its antibacterial activity / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 332-335, 2018.
Article
em Zh
| WPRIM
| ID: wpr-771733
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WPRO
ABSTRACT
A new isoflavone derivative was isolated from Rosa damascena by using various chromatographic techniques including silica gel, Sephadex LH-20, and preparative RP-HPLC separation. Its structure was identified as 4'-hydroxy-7-(3-hydroxypropanoyl)-6-methoxy-isoflavone using combined examinations of their UV, IR, MS, and NMR spectroscopic data. Biological activity test showed that this compound showed prominent antibacterial activity with MIC₉₀ value of (46±4) mg·L⁻¹ for methicillin resistant Staphylococcus aureus(MRSA) strain. This value is close to that of levofloxacin [with MIC₉₀ value (53±5) mg·L⁻¹].
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Assunto principal:
Farmacologia
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Testes de Sensibilidade Microbiana
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Química
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Rosa
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Staphylococcus aureus Resistente à Meticilina
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Compostos Fitoquímicos
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Isoflavonas
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Antibacterianos
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2018
Tipo de documento:
Article