Gene knockout technology and its application in the study of the relationship between mitochondrial dynamics and insulin resistance / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1382-1390, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-771791
ABSTRACT
Mitochondrial dynamics, the processes of mitochondrial fusion and fission maintain homeostasis, are precisely regulated by fusion/fission-related proteins, and play an important physiological role in mitochondrial metabolism, quality and function. The aberrant changes of these proteins can trigger mitochondrial dynamics imbalance, which cause mitochondrial dysfunctions and result various disease states. This article focuses on gene knockout technology, and reviews the role and application progress of genes encoding for fusion and fission knockout mice in insulin resistance researches, in order to lay a foundation for future studies on signal transduction mechanism of mitochondrial dynamics imbalance in insulin resistance.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Resistência à Insulina
/
Proteínas Mitocondriais
/
Técnicas de Inativação de Genes
/
Dinâmica Mitocondrial
/
Mitocôndrias
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Biotechnology
Ano de publicação:
2019
Tipo de documento:
Artigo
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