Advances in the application of claudins to tumor therapy / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 931-941, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-771833
ABSTRACT
Claudin proteins are the most crucial components of tight junctions, and play an essential role in maintaining cell polarity, regulating cell permeability and the intercellular ion. In recent years, many studies have shown that abnormality of claudins expression is implicated in the tumor progression. The expression correlates with tumor prognosis and can serve as a biomarker of prognosis and potential therapeutic targets. This review summarizes the current knowledge regarding claudin dysregulation in cancer and highlights the progress in claudin-based treatments.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Junções Íntimas
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Enterotoxinas
/
Claudinas
/
Neoplasias
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Biotechnology
Ano de publicação:
2019
Tipo de documento:
Artigo
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