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Association of STK39 gene polymorphism with response to hydrochlorothiazide among ethnic Han Chinese with essential hypertension / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 639-644, 2019.
Artigo em Chinês | WPRIM | ID: wpr-771948
ABSTRACT
OBJECTIVE@#To assess the association of single nucleotide polymorphisms (SNPs) of STK39 gene with response to hydrochlorothiazide among ethnic Han Chinese patients with essential hypertension.@*METHODS@#In total 118 patients with essential hypertension were recruited. All participants had received six weeks of treatment with hydrochlorothiazide 25 mg daily. Blood pressure (BP) and heart rate (HR) were measurement every 2 weeks. Genotypes of STK39 rs3754777 and rs6749447 were determined using a SNaPshot technique.@*RESULTS@#A significant difference was found in ΔSBP between individuals with rs3754777 CC, CT and TT and those with rs3754777 CC and CT-TT (P0.05). Relative risk analysis showed that STK39 rs3754777 was significantly associated with BP response to hydrochlorothiazide (OR=0.416, 95%CI=0.189-0.918, P<0.05).@*CONCLUSION@#Polymorphisms of STK39 rs3754777 may be associated with BP response to hydrochlorothiazide among ethnic Han Chinese with essential hypertension.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Proteínas Serina-Treonina Quinases / Polimorfismo de Nucleotídeo Único / Povo Asiático / Hipertensão Essencial / Genética / Genótipo / Hidroclorotiazida Tipo de estudo: Estudo de etiologia Limite: Humanos Idioma: Chinês Revista: Chinese Journal of Medical Genetics Ano de publicação: 2019 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Proteínas Serina-Treonina Quinases / Polimorfismo de Nucleotídeo Único / Povo Asiático / Hipertensão Essencial / Genética / Genótipo / Hidroclorotiazida Tipo de estudo: Estudo de etiologia Limite: Humanos Idioma: Chinês Revista: Chinese Journal of Medical Genetics Ano de publicação: 2019 Tipo de documento: Artigo