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Papain Induced Occupational Asthma with Kiwi and Fig Allergy
Allergy, Asthma & Immunology Research ; : 170-173, 2016.
Artigo em Inglês | WPRIM | ID: wpr-77204
ABSTRACT
Papain is a proteolytic enzyme which is widely used in food industry, pharmaceuticals, and cosmetics. Occupational and non-occupational papain allergies have previously been documented; however, there are limited publications about papain allergy with its relative fruit allergy. Here, we present a case of occupational, IgE-mediated papain allergy with kiwi fruit and fig fruit allergy. A 53-year-old man suffered from rhinitis for several years, with the onset of his symptoms coinciding with the time he started to work at a sausage processing plant where papain is often used as a meat tenderizer. He began to experience symptoms of chest tightness, shortness of breath and wheezing shortly after starting work 5 years ago. Furthermore, he experienced several episodes of oral itching, and tongue and oropharyngeal angioedema after injestion of kiwi fruit and fig fruit. The patient had a lifelong history of allergic conjunctivitis, allergic rhinitis, and childhood asthma. Specific IgE was positive to kiwi fruit, papain and chymopapain (2.95 kUA/L, >100 kUA/L, and 95.0 kUA/L, respectively). Similar bands at 10-15 kDa in blotting with papain and kiwi fruit extracts were found. This patient showed a potential association between papain allergy and sensitization to kiwi fruit. We also reviewed 13 patients with papain allergy published in the literature, with 85% (11/13) of the patients sensitized through the respiratory tract, and 40% (4/11) having atopy. Further studies should focus on the determination of cross-reactive allergens between papain and its fruit relatives, and the prevalence of food allergy in patients with papain allergy should be investigated in a relatively large cohort.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Plantas / Prurido / Sistema Respiratório / Asma / Tórax / Língua / Conjuntivite Alérgica / Imunoglobulina E / Alérgenos / Quimopapaína Tipo de estudo: Estudo de etiologia / Estudo de incidência / Estudo observacional / Estudo de prevalência / Fatores de risco Limite: Humanos Idioma: Inglês Revista: Allergy, Asthma & Immunology Research Ano de publicação: 2016 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Plantas / Prurido / Sistema Respiratório / Asma / Tórax / Língua / Conjuntivite Alérgica / Imunoglobulina E / Alérgenos / Quimopapaína Tipo de estudo: Estudo de etiologia / Estudo de incidência / Estudo observacional / Estudo de prevalência / Fatores de risco Limite: Humanos Idioma: Inglês Revista: Allergy, Asthma & Immunology Research Ano de publicação: 2016 Tipo de documento: Artigo