Structure and function of B-cell linker and its role in the development of B cell-related diseases / 南方医科大学学报
Journal of Southern Medical University
;
(12): 253-256, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-772090
ABSTRACT
B cell linker (BLNK) is a key linker protein of B cell receptor (BCR) signaling pathway. BLNK participates in the regulation of PLC-γactivity and the activation of Ras pathway through its typical structure and interaction network with other proteins, and is thus widely involved in the regulation of B cell proliferation, differentiation, apoptosis and signal transduction. Furthermore, it is closely related to anaphylactic diseases, multiple sclerosis, chromosomal aneuploidy, aneuglobulinemia, B lymphocytic leukemia and lymphoma. Herein we review the structure and biological function of BLNK and its role in B cell-related diseases. BLNK can cooperate with a series of effective proteins to activate BCR signaling pathway, thereby regulating the development, maturation and function of B cells. The functional mutation of BLNK can destroy the homeostasis of B cells and affect the development and maturation of B cells, which leads to the occurrence of B cell related diseases. A comprehensive understanding of the biological functions of BLNK not only provides insights into the pathogenesis of B cell-related diseases, but also inspires new ideas and helps to find breakthroughs for the treatment of these diseases with BLNK as the therapeutic target.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Relação Estrutura-Atividade
/
Linfócitos B
/
Receptores de Antígenos de Linfócitos B
/
Transdução de Sinais
/
Diferenciação Celular
/
Química
/
Apoptose
/
Biologia Celular
/
Proteínas Adaptadoras de Transdução de Sinal
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2019
Tipo de documento:
Artigo
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