Changes of Wnt/β-catenin signaling pathway in the hippocampus caused by prenatal stress induce depression- and anxiety-like behaviors in rats / 南方医科大学学报
Journal of Southern Medical University
;
(12): 222-226, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-772095
ABSTRACT
OBJECTIVE@#To explore the pathogenic role of changes of Wnt/β-catenin signaling pathway in the hippocampus in depression- and anxiety-like behaviors caused by prenatal stress (PS) in offspring rats.@*METHODS@#Twelve female SpragueDawley rats weighing 240-260 g were randomly divided into control and restraint stress groups. The rats in the control group received no interventions, and those in restraint stress group were subjected to restraint stress (three times a day, 45 min each time) at the gestational age of 14-20 days. The 1-month-old offspring rats underwent open field test and forced swimming test to assess the anxiety- and depression-like behaviors, and the expressions of Wnt1, Gsk-3β and β-catenin in the hippocampus were detected using Western blotting.@*RESULTS@#In open field test, the offspring rats with PS showed significantly decreased crossings of the center ( < 0.01) with reduced time spent in the center ( < 0.05) compared with control offspring rats. In forced swimming test, the offspring rats in PS group exhibited a significantly longer immobility time than in the control rats, and showed obvious depression- and anxiety-like behaviors. Compared with those in the control offspring rats, Gsk-3β expression increased significantly while the expressions of β-catenin and Wnt1 were significantly lowered in the hippocampus of the offspring rats in PS group ( < 0.01).@*CONCLUSIONS@#PS causes changes in Wnt/β-catenin signaling pathway in the hippocampus to contribute to the occurrence of depression-and anxiety-like behaviors in rats.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ansiedade
/
Psicologia
/
Estresse Psicológico
/
Natação
/
Comportamento Animal
/
Restrição Física
/
Distribuição Aleatória
/
Ratos Sprague-Dawley
/
Depressão
/
Via de Sinalização Wnt
Limite:
Animais
/
Gravidez
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2019
Tipo de documento:
Artigo
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