Invasion and metastasis mechanism of human papillomavirus in head and neck squamous cell carcinomas / 华西口腔医学杂志
West China Journal of Stomatology
; (6): 544-551, 2018.
Article
em Zh
| WPRIM
| ID: wpr-772461
Biblioteca responsável:
WPRO
ABSTRACT
Human papillomavirus (HPV) is a major causative agent of head and neck squamous cell carcinomas (HNSCC). Over the past several decades, an increasing number of studies established the strong association of HPV with the invasion and metastasis of HNSCC. In the present study, we reviewed the gene mutations in HPV-associated HNSCC and the unique mechanism of E6- and E7-mediated carcinogenesis via interactions with an array of cellular elements. We further discussed the progress in the mechanisms of invasion and metastasis; these mechanisms include non-coding RNAs, deregulating cellular energetics, tumor microenvironment, cancer stem cells, angiogenesis, and lymphangiogenesis.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Papillomaviridae
/
Patologia
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Virologia
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Infecções por Papillomavirus
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Carcinoma de Células Escamosas de Cabeça e Pescoço
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Neoplasias de Cabeça e Pescoço
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Invasividade Neoplásica
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Metástase Neoplásica
Limite:
Humans
Idioma:
Zh
Revista:
West China Journal of Stomatology
Ano de publicação:
2018
Tipo de documento:
Article