Interferon-α salvage treatment is effective for patients with acute leukemia/myelodysplastic syndrome with unsatisfactory response to minimal residual disease-directed donor lymphocyte infusion after allogeneic hematopoietic stem cell transplantation / 医学前沿
Frontiers of Medicine
; (4): 238-249, 2019.
Article
em En
| WPRIM
| ID: wpr-772707
Biblioteca responsável:
WPRO
ABSTRACT
The efficacy of salvage interferon-α (IFN-α) treatment was investigated in patients with unsatisfactory response to minimal residual disease (MRD)-directed donor lymphocyte infusion (DLI) (n = 24). Patients who did not become MRD-negative at 1 month after DLI were those with unsatisfactory response and were eligible to receive salvage IFN-α treatment within 3 months of DLI. Recombinant human IFN-α-2b injections were subcutaneously administered 2-3 times a week for 6 months. Nine (37.5%), 6 (25.0%), and 3 (12.5%) patients became MRD-negative at 1, 2, and > 2 months after the salvage IFN-α treatment, respectively. Two-year cumulative incidences of relapse and non-relapse mortality were 35.9% and 8.3%, respectively. Two-year probabilities of event-free survival, disease-free survival, and overall survival were 51.6%, 54.3%, and 68.0%, respectively. Outcomes of patients subjected to salvage IFN-α treatment after DLI were significantly better than those with persistent MRD without IFN-α treatment. Moreover, clinical outcomes were comparable between the salvage DLI and IFN-α treatment groups. Thus, salvage IFN-α treatment may help improve the outcome of patients with unsatisfactory responses to MRD-directed DLI and could be a potential salvage treatment for these patients after allogeneic hematopoietic stem cell transplantation.
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Índice:
WPRIM
Assunto principal:
Recidiva
/
Terapêutica
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Transplante Homólogo
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Síndromes Mielodisplásicas
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Leucemia Mieloide Aguda
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Protocolos de Quimioterapia Combinada Antineoplásica
/
Análise de Sobrevida
/
Mortalidade
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Terapia de Salvação
/
Interferon-alfa
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
/
Adult
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Child
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Child, preschool
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Female
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Frontiers of Medicine
Ano de publicação:
2019
Tipo de documento:
Article