NKT cells in liver diseases / 医学前沿
Frontiers of Medicine
;
(4): 249-261, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-772711
ABSTRACT
Natural killer T cells are innate-like and tissue-resident lymphocytes, which recognize lipid antigens and are enriched in the liver. Natural killer T cells play important roles in infections, tumors, autoimmune diseases, and metabolic diseases. In this study, we summarize recent findings on biology of natural killer T cells and their roles in hepatitis B virus and hepatitis C virus infection, autoimmune liver diseases, alcoholic liver disease, nonalcoholic fatty liver disease, and hepatocellular carcinoma. Controversial results from previous studies are discussed, and indicate the dynamic alteration in the role of natural killer T cells during the progression of liver diseases, which might be caused by changes in natural killer T subsets, factors skewing cytokine responses, and intercellular crosstalk between natural killer T cells and CD1d-expressing cells or bystander cells.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Doenças Autoimunes
/
Alergia e Imunologia
/
Células T Matadoras Naturais
/
Fígado
/
Hepatopatias
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Frontiers of Medicine
Ano de publicação:
2018
Tipo de documento:
Artigo
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