γδ T cells in liver diseases / 医学前沿
Frontiers of Medicine
; (4): 262-268, 2018.
Article
em En
| WPRIM
| ID: wpr-772720
Biblioteca responsável:
WPRO
ABSTRACT
γδ T cells display unique developmental, distributional, and functional patterns and can rapidly respond to various insults and contribute to diverse diseases. Different subtypes of γδ T cells are produced in the thymus prior to their migration to peripheral tissues. γδ T cells are enriched in the liver and exhibit liver-specific features. Accumulating evidence reveals that γδ T cells play important roles in liver infection, non-alcoholic fatty liver disease, autoimmune hepatitis, liver fibrosis and cirrhosis, and liver cancer and regeneration. In this study, we review the properties of hepatic γδ T cells and summarize the roles of γδ T cells in liver diseases. We believe that determining the properties and functions of γδ T cells in liver diseases enhances our understanding of the pathogenesis of liver diseases and is useful for the design of novel γδ T cell-based therapeutic regimens for liver diseases.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Citocinas
/
Linfócitos T Reguladores
/
Alergia e Imunologia
/
Hepatopatias
/
Regeneração Hepática
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Frontiers of Medicine
Ano de publicação:
2018
Tipo de documento:
Article