Associations between Mycobacterium tuberculosis Beijing genotype and drug resistance to four first-line drugs: a survey in China / 医学前沿
Frontiers of Medicine
;
(4): 92-97, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-772732
ABSTRACT
Investigations on the genetic diversity of Mycobacterium tuberculosis in China have shown that Beijing genotype strains play a dominant role. To study the association between the M. tuberculosis Beijing genotype and the drug-resistance phenotype, 1286 M. tuberculosis clinical isolates together with epidemiological and clinical information of patients were collected from the center for tuberculosis (TB) prevention and control or TB hospitals in Beijing municipality and nine provinces or autonomous regions in China. Drug resistance testing was conducted on all the isolates to the four first-line anti-TB drugs (isoniazid, rifampicin, streptomycin, and ethambutol). A total of 585 strains were found to be resistant to at least one of the four anti-TB drugs. The Beijing family strains consisted of 499 (53.20%) drug-sensitive strains and 439 (46.80%) drug-resistant strains, whereas the non-Beijing family strains comprised 202 (58.05%) drug-sensitive strains and 146 (41.95%) drug-resistant strains. No significant difference was observed in prevalence (χ= 2.41, P > 0.05) between the drug-resistant and drugsensitive strains among the Beijing family strains. Analysis of monoresistance, multidrug-resistant TB, and geographic distribution of drug resistance did not find any relationships between the M. tuberculosis Beijing genotype and drug-resistance phenotype in China. Results confirmed that the Beijing genotype, the predominant M. tuberculosis genotype in China, was not associated with drug resistance.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenótipo
/
Variação Genética
/
Testes de Sensibilidade Microbiana
/
China
/
Epidemiologia
/
Tuberculose Resistente a Múltiplos Medicamentos
/
Farmacorresistência Bacteriana Múltipla
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Genética
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Frontiers of Medicine
Ano de publicação:
2018
Tipo de documento:
Artigo
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