Prevalence of vitamin D deficiency in girls with idiopathic central precocious puberty / 医学前沿
Frontiers of Medicine
;
(4): 174-181, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-772757
ABSTRACT
The relationship between vitamin D deficiency and idiopathic central precocious puberty (ICPP) has been recently documented. In this study, 280 girls diagnosed with ICPP and 188 normal puberty control girls of similar ages were enrolled and retrospectively studied. The ICPP group had significantly lower serum 25-hydroxyvitamin D (25[OH]D) levels than the control group. Furthermore, a nonlinear relationship was found between serum 25[OH]D and ICPP, and a cut-off point for serum 25[OH]D was found at 31.8 ng/ml for ICPP with and without adjusting the different confounding factors. Girls with serum 25[OH]D ≥ 31.8 ng/ml had a lower odds ratio (unadjusted OR 0.36, 95% CI 0.15 to 0.83, P < 0.05; height and weight adjusted OR 0.44, 95% CI 0.18 to 1.08, P = 0.072; BMI adjusted OR 0.36, 95% CI 0.16 to 0.84, P < 0.05). The ICPP subjects with 25[OH]D deficiency had a higher body mass index (BMI) than the subjects from the two other subgroups. Correlation analysis showed that vitamin D level is correlated with BMI and some metabolic parameters in the ICPP group. Our study suggested that vitamin D status may be associated with ICPP risk and may have a threshold effect on ICPP.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Puberdade Precoce
/
Vitamina D
/
Deficiência de Vitamina D
/
Sangue
/
Índice de Massa Corporal
/
Modelos Lineares
/
Modelos Logísticos
/
China
/
Epidemiologia
/
Análise Multivariada
Tipo de estudo:
Estudo observacional
/
Estudo de prevalência
/
Estudo prognóstico
/
Fatores de risco
Limite:
Criança
/
Feminino
/
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Frontiers of Medicine
Ano de publicação:
2018
Tipo de documento:
Artigo
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