Stability of a type 2 diabetes rat model induced by high-fat diet feeding with low-dose streptozotocin injection / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
;
(12): 559-569, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-772766
ABSTRACT
OBJECTIVE@#The present study aims at determining the stability of a popular type 2 diabetes rat model induced by a high-fat diet combined with a low-dose streptozotocin injection.@*METHODS@#Wistar rats were fed with a high-fat diet for 8 weeks followed by a one-time injection of 25 or 35 mg/kg streptozotocin to induce type 2 diabetes. Then the diabetic rats were fed with regular diet/high-fat diet for 4 weeks. Changes in biochemical parameters were monitored during the 4 weeks.@*RESULTS@#All the rats developed more severe dyslipidemia and hepatic dysfunction after streptozotocin injection. The features of 35 mg/kg streptozotocin rats more resembled type 1 diabetes with decreased body weight and blood insulin. Rats with 25 mg/kg streptozotocin followed by normal diet feeding showed normalized blood glucose level and pancreatic structure, indicating that normal diet might help recovery from certain symptoms of type 2 diabetes. In comparison, diabetic rats fed with high-fat diet presented decreased but relatively stable blood glucose level, and this was significantly higher than that of the control group (P<0.05).@*CONCLUSIONS@#This model easily recovers with normal diet feeding. A high-fat diet is suggested as the background diet in future pharmacological studies using this model.
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Assunto principal:
Patologia
/
Superóxido Dismutase
/
Ácido Úrico
/
Sangue
/
Glicemia
/
Ratos Wistar
/
Estreptozocina
/
Estresse Oxidativo
/
Diabetes Mellitus Experimental
/
Diabetes Mellitus Tipo 2
Limite:
Animais
Idioma:
Inglês
Revista:
Journal of Zhejiang University. Science. B
Ano de publicação:
2018
Tipo de documento:
Artigo
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