Mechanisms and implications of cancer cell dormancy in head and neck carcinoma / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 92-98, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-773289
ABSTRACT
Disease metastasis and relapse in many cancer patients several years (even decades) after surgical remission have been recently acknowledged as cases of cancer dormancy. Although cases of minimal residual disease are well documented, knowledge on its biological mechanisms and clinical implications remains limited. To date, numerous reviews have summarized the three potential models that may explain this phenomenon, including the angiogenic, immunologic, and cellular dormancy. In this study, we discuss newly uncovered mechanisms governing tumor cell dormancy in head and neck cancer, emphasizing on the crosstalk between dormant tumor cells and their microenvironments. Additionally, we explore the mechanisms on the reactivation of dormant residual tumor cells in anatomical sites, including the lymph nodes and bone marrow.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Medula Óssea
/
Neoplasia Residual
/
Microambiente Tumoral
/
Neoplasias de Cabeça e Pescoço
/
Linfonodos
/
Recidiva Local de Neoplasia
Limite:
Humanos
Idioma:
Chinês
Revista:
West China Journal of Stomatology
Ano de publicação:
2018
Tipo de documento:
Artigo
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