Discovery of novel limonin derivatives as potent anti-inflammatory and analgesic agents / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 231-240, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-773618
ABSTRACT
Novel series of limonin derivatives (V-A-1-V-A-8, V-B-1-V-B-8) were synthesized by adding various tertiary amines onto the C (7)-position of limonin. The synthesized compounds possessed favorable physicochemical property, and the intrinsic solubility of the novel compounds were significantly improved, compared with limonin. Different pharmacological models were used to evaluate the analgesic and anti-inflammatory activities of the target compounds. Compound V-A-8 exhibited the strongest in vivo activity among the novel limonin analogs; its analgesic activity was more potent than aspirin and its anti-inflammatory activity was stronger than naproxen under our testing conditions.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Dor
/
Estrutura Molecular
/
Química
/
Limoninas
/
Tratamento Farmacológico
/
Edema
/
Descoberta de Drogas
/
Analgésicos
/
Anti-Inflamatórios
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2018
Tipo de documento:
Artigo
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