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Sedative and antinociceptive activities of two new sesquiterpenes isolated from Ricinus communis / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.) ; (6): 225-230, 2018.
Artigo em Inglês | WPRIM | ID: wpr-773619
ABSTRACT
Two new sesquiterpenes, trivially named ricinusoids A (1) and ricinusoids B (2), were isolated from ethyl acetate fraction of Ricinus communis. The structures of new compounds were elucidated by detailed spectroscopic techniques, including 1D- and 2D-NMR, UV, IR spectroscopy, and mass spectrometry. The compounds (1-2) were also assessed for in-vivo sedative and analgesic like effects in open field and acetic acid induced writhing tests respectively at 5, 10, and 20 mg·kg i.p. Pretreatment of both test compounds caused significant (P ≤ 0.05) reduction in locomotive activity like sedative agents and abdominal constrictions like analgesics. Both compounds (1-2) possessed marked sedative and antinociceptive effects in animal models.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Dor / Ricinus / Sesquiterpenos / Extratos Vegetais / Estrutura Molecular / Química / Folhas de Planta / Tratamento Farmacológico / Analgésicos / Hipnóticos e Sedativos Limite: Animais / Humanos / Masculino Idioma: Inglês Revista: Chinese Journal of Natural Medicines (English Ed.) Ano de publicação: 2018 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Dor / Ricinus / Sesquiterpenos / Extratos Vegetais / Estrutura Molecular / Química / Folhas de Planta / Tratamento Farmacológico / Analgésicos / Hipnóticos e Sedativos Limite: Animais / Humanos / Masculino Idioma: Inglês Revista: Chinese Journal of Natural Medicines (English Ed.) Ano de publicação: 2018 Tipo de documento: Artigo