Changes of some biochemical markers and cardiac function in New Zealand rabbits with chronic heart failure / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 74-77, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-773799
ABSTRACT
OBJECTIVE@#This article investigated the changes of some biochemical markers and cardiac function in chronic heart failure (CHF), and provided the basis for the diagnosis of CHF.@*METHODS@#New Zealand rabbit CHF model was established using adriamycin (ADR). Twenty New Zealand rabbits were randomly divided into model group (=15) and control group (=5), injected with ADR and saline solution the ear vein respectively, 2 times a week, lasting for 8 weeks. After that, myocardial enzymes, carotid artery pressure, echocardiogram (ECG) and phonocardiogram (PCG) of all New Zealand rabbits were detected and recorded.@*RESULTS@#Compared with control group, all parameters of the model group were changed significantly (<0.05).@*CONCLUSIONS@#CHF leads to myocardial damage in New Zealand rabbits, decreased systolic and diastolic function, cardiac reserve index can be used to assess cardiac function.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fonocardiografia
/
Pressão Sanguínea
/
Biomarcadores
/
Artérias Carótidas
/
Doxorrubicina
/
Distribuição Aleatória
/
Doença Crônica
/
Eletrocardiografia
/
Insuficiência Cardíaca
/
Miocárdio
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2018
Tipo de documento:
Artigo
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