The role of myeloid-derived suppressor cells in glioma microenvironment / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 515-520, 2019.
Article
em Zh
| WPRIM
| ID: wpr-774176
Biblioteca responsável:
WPRO
ABSTRACT
Glioma is one of the most common primary tumors in the human brain with poor prognosis. The local and systemic immunosuppressive environment created by glioma cells enables them to evade immunosurveillance. Myeloid-derived suppressor cells (MDSCs) are a critical component of the immunosuppression system. They are a heterogeneous cell population composed of early myeloid progenitor cells and precursor cells. Although the cells are diverse in phenotypes and functions, they all have strong immunosuppressive functions. MDSCs are extensively infiltrated into tumor tissues and play an important role in the glioma immunosuppressive microenvironment, which also hinders the immunotherapeutic effects of glioma. This article will review the phenotypic characteristics of MDSCs in the glioma microenvironment and their role in the progression of glioma. It is of positive significance to better understand the pathogenesis of glioma and explore effective comprehensive treatments.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Patologia
/
Biologia Celular
/
Microambiente Tumoral
/
Células Supressoras Mieloides
/
Glioma
/
Tolerância Imunológica
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
Zh
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2019
Tipo de documento:
Article